AmiGO 2: Term Details for "signal transduction" (GO:0007165)

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Term Information

Accession: GO:0007165
Name: signal transduction
Ontology: biological_process
Synonyms: signaling pathway, signalling pathway, signaling cascade, signalling cascade
Alternate IDs: GO:0023016, GO:0023014, GO:0023015, GO:0023045, GO:0023033
Definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Source: GOC:curators, GOC:mtg_signaling_feb11
Comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
History: See term history for GO:0007165 at QuickGO
Chem. react.: None
Subset: goslim_metagenomics; goslim_chembl; goslim_plant; goslim_plant_ribbon; goslim_candida
Related: Link to all genes and gene products annotated to signal transduction (excluding "regulates").; Link to all direct and indirect annotations to signal transduction (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for signal transduction (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0038183 bile acid signaling pathway
GO:0009756 carbohydrate mediated signaling
GO:0007166 cell surface receptor signaling pathway
GO:0106167 extracellular ATP signaling
GO:0007186 G protein-coupled receptor signaling pathway
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0071588 hydrogen peroxide mediated signaling pathway
GO:0002764 immune response-regulating signaling pathway
GO:0035556 intracellular signal transduction
GO:1990806 ligand-gated ion channel signaling pathway
GO:0055095 lipoprotein particle mediated signaling
GO:0097527 necroptotic signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0023041 neuronal signal transduction
GO:0140626 opioid growth factor receptor signaling pathway
GO:0007602 phototransduction
GO:0009967 positive regulation of signal transduction
GO:0098926 postsynaptic signal transduction
GO:0098928 presynaptic signal transduction
GO:0048018 receptor ligand activity
GO:0010017 red or far-red light signaling pathway
GO:0010850 regulation of blood pressure by chemoreceptor signaling pathway
GO:0060863 regulation of floral organ abscission by signal transduction
GO:0009966 regulation of signal transduction
GO:0009863 salicylic acid mediated signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0038034 signal transduction in absence of ligand
GO:1903831 signal transduction involved in cellular response to ammonium ion
GO:0001402 signal transduction involved in filamentous growth
GO:0023019 signal transduction involved in regulation of gene expression
GO:0090520 sphingolipid mediated signaling pathway

Parents of signal transduction (GO:0007165)

subject	relation	object
signal transduction	BFO:0000050	cellular response to stimulus (GO:0051716)
signal transduction	is_a	cellular process (GO:0009987)
signal transduction	BFO:0000050	signaling (GO:0023052)
signal transduction	BFO:0000050	cell communication (GO:0007154)
signal transduction	is_a	regulation of cellular process (GO:0050794)

Children of signal transduction (GO:0007165)

subject	relation	object
granzyme-mediated programmed cell death signaling pathway (GO:0140507)	is_a	signal transduction
regulation of floral organ abscission by signal transduction (GO:0060863)	is_a	signal transduction
salicylic acid mediated signaling pathway (GO:0009863)	is_a	signal transduction
positive regulation of signal transduction (GO:0009967)	RO:0002213	signal transduction
hormone-mediated signaling pathway (GO:0009755)	is_a	signal transduction
signal transduction involved in filamentous growth (GO:0001402)	is_a	signal transduction
receptor ligand activity (GO:0048018)	BFO:0000050	signal transduction
lipoprotein particle mediated signaling (GO:0055095)	is_a	signal transduction
neuronal signal transduction (GO:0023041)	is_a	signal transduction
sphingolipid mediated signaling pathway (GO:0090520)	is_a	signal transduction
bile acid signaling pathway (GO:0038183)	is_a	signal transduction
cell surface receptor signaling pathway (GO:0007166)	is_a	signal transduction
signal transduction involved in cellular response to ammonium ion (GO:1903831)	is_a	signal transduction
symbiont-mediated suppression of host signal transduction pathway (GO:0052029)	RO:0012014	signal transduction
opioid growth factor receptor signaling pathway (GO:0140626)	is_a	signal transduction
postsynaptic signal transduction (GO:0098926)	is_a	signal transduction
regulation of signal transduction (GO:0009966)	RO:0002211	signal transduction
symbiont-mediated perturbation of host signal transduction pathway (GO:0052027)	RO:0002010	signal transduction
apoptotic signaling pathway (GO:0097190)	is_a	signal transduction
serotonin receptor signaling pathway (GO:0007210)	is_a	signal transduction
programmed cell death (GO:0012501)	RO:0002224	signal transduction
venom-mediated perturbation of signal transduction (GO:0044509)	RO:0002010	signal transduction
G protein-coupled receptor signaling pathway (GO:0007186)	is_a	signal transduction
intracellular signal transduction (GO:0035556)	is_a	signal transduction
presynaptic signal transduction (GO:0098928)	is_a	signal transduction
red or far-red light signaling pathway (GO:0010017)	is_a	signal transduction
signal transduction involved in regulation of gene expression (GO:0023019)	is_a	signal transduction
negative regulation of signal transduction (GO:0009968)	RO:0002212	signal transduction
necroptotic signaling pathway (GO:0097527)	is_a	signal transduction
immune response-regulating signaling pathway (GO:0002764)	is_a	signal transduction
phototransduction (GO:0007602)	is_a	signal transduction
regulation of blood pressure by chemoreceptor signaling pathway (GO:0010850)	is_a	signal transduction
hydrogen peroxide mediated signaling pathway (GO:0071588)	is_a	signal transduction
ligand-gated ion channel signaling pathway (GO:1990806)	is_a	signal transduction
carbohydrate mediated signaling (GO:0009756)	is_a	signal transduction
extracellular ATP signaling (GO:0106167)	is_a	signal transduction
signal transduction in absence of ligand (GO:0038034)	is_a	signal transduction
symbiont-mediated activation of host signal transduction pathway (GO:0052028)	RO:0012013	signal transduction

Reactome: R-HSA-212718
Wikipedia: Signal_transduction

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